Custom Peptides
Cayman Chemical tnofovIr DIsoproxIlfumart 10mg
A prodrug of the HIV reverse transcriptase and hepatitis B virus polymerase inhibitor, tenofovir; >100-fold greater anti-HIV activity than that of poorly bioavailable tenofovir in a T cell line and primary blood lymphocytes
Cayman Chemical Tegatrabetn 10mg
An inhibitor of Wnt/β-catenin signaling; reduces Wnt3a-induced transcriptional activity in a reporter activity assay using STF3a cells, which exhibit constituitive Wnt activation, at 1 µM; inhibits proliferation of, and DNA transcription in, HT-29 cells (IC50s = 9 and 63 nM, respectively) and reduces survival in six other cancer cell lines (IC50s = 14-80 nM); induces cell cycle arrest at the G1 phase in HCT-15 cells at 625 nM; reduces tumor volume and inhibits lung metastasis in a Saos-2 osteosarcoma xenograft mouse model at 50 mg/kg per day
Cayman Chemical BradykInInhumnmouserat 10mg
An endogenous vasodilator; binds to the bradykinin B2 receptor (IC50 = 0.54 nM in COS-7 cells expressing the human receptor) and acts as an agonist but does not bind the bradykinin B1 receptors (Ki = >10,000 nM in HEK293 cells expressing the human receptor); stimulates arachidonic acid release in CHO cells expressing the human bradykinin B2 receptor (EC50 = 0.7 nM); induces relaxation of ACh- or PDBu precontracted isolated porcine coronary arterial rings at 100 nM; induces hyperalgesia in mice at 1 UG/paw; plasma levels are increased in patients during an acute attack of angioedema
Cayman Chemical BenIdIpInhydrochlorIde 10mg
An orally bioavailable inhibitor of L-, T-, and N-type calcium channels; IC50 = 2.7 nM in guinea pig ventricular cells; prevents oxidative stress in vitro and in neural stem cells; has antihypertensive effects; competitive antagonist at mineralocorticoid receptors
Cayman Chemical 6-MAPBhydrochlorIde 10mg
An analytical reference standard categorized as a benzofuran; intended for research and forensic applications
Cayman Chemical DeferasIrox 10mg
An orally bioavailable iron chelator with anticancer activity; selective for (Fe(III) over Cu(II), Zn(II), Mg(II), and Ca(II) but does bind to Al(III); decreases iron levels in iron-loaded rat heart cells in vitro by 45.8 and 55.6% compared to control levels at 160 and 320 µM; decreases radiolabeled liver iron levels from 41 to 21.7% and blood iron levels from 8.2 to 3.4% in hypertransfused rats at 200 mg/kg; inhibits proliferation of SAS human oral squamous carcinoma cells (EC50 = 21 µM); act synergistically with gemcitabine in vitro to inhibit proliferation and in vivo to reduce tumor growth at 200 mg/kg in a BxPC-3 mouse xenograft model
Cayman Chemical CyclogunIlhydrochlorIde 10mg
The active metabolite of proguanil; formed from proguanil by CYP2C19 and CYP3A in human liver microsomes; an inhibitor of DHFR (Kis = 1.5 and 0.79 nM for the P. falciparum and P. berghei enzymes, respectively); active against ten P. falciparum field isolates (IC50s = 0.12-1,400 UG/ml); reduces parasitemia in a mouse model of P. berghei infection (ED50 = 2 mg/kg); reduces parasitemia in a rhesus monkey model of P. cynomolgi infection at 0.3 mg/kg
Cayman Chemical BufuralolhydrochlorIde 10mg
A non-selective antagonist of β-ARs that also has partial agonist activity; decreases mean arterial blood pressure and increases abdominal aortic blood flow in anesthetized cats at 0.3 and 1 mg/kg; has been used as a substrate to measure CYP2D6 activity
Cayman Chemical JWH398 6CLORNaphthyl Isom 10mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids; intended for research and forensic applications
Cayman Chemical R-2 MethndamIde 10mg
A CB analog with a methyl group in the (R) configuration at C-2 of the ethanolamine group; is not a FAAH inhibitor and is nearly as susceptible to amide hydrolysis as AEA itself
Cayman Chemical PItofenonhydrochlorIde 10mg
An antispasmodic agent; an inhibitor of AChE (Kis = 36 and 45 μM for bovine erythrocyte and electric eel enzyme, respectively); inhibits acetylcholine-induced contractions of isolated guinea pig ileum at 2.5 μM
Cayman Chemical DIbutyl3Hydroybutyl phsph 10mg
A compound produced from the metabolism of the organophosphorus solvent, TBP
Cayman Chemical DelafloxacIn 10mg
A fluoroquinolone antibiotic that demonstrates extremely high potency against a wide range of bacteria in vitro; has an anionic structure, which enhances its potency in acidic environments and in skin and soft tissue infections
Cayman Chemical BatbulInsodIum salt 10mg
An inhibitor of tubulin polymerization; covalently binds to Cys239 of the β1, β2, and β4 tubulin isotypes and inhibits polymerization of bovine brain tubulin (IC50 = 2 µM) in cell-free assays; induces cytoskeletal collapse and cell cycle arrest at the G2/M phase in MCF-7 cells at 30, 100, and 300 nM; cytotoxic against a panel of drug-sensitive and -resistant cancer cell lines (IC50s = 11-165 nM); reduces tumor volume in CCRF CEM and CEM/VBL100 mouse xenograft models
Cayman Chemical 15hydroxy PentadecNIc ACD 10mg
A hydroxylated fatty acid; has been used in the synthesis of the macrocyclic lactone musk compounds exaltolide and phoracantholide I